Risk/benefit profile of St.John's wort extract: STEI 300 in 2404 patients with various degrees of psychiatric disturbance. Johne A, Brockmoller J, Bauer S, et al. View abstract. View abstract. J Geriatr.Psychiatry Neurol. This could decrease how well phenobarbital works. Drug Metab Dispos 2004;32:512-8. Carpenter, S. and Kraus, G. A. Photosensitization is required for inactivation of equine infectious anemia virus by hypericin. Hall SD, Wang Z, Huang SM, et al. View abstract. In vitro metabolism of hyperforin in rat liver microsomal systems. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Int J Clin Pharmacol Ther 2000;38:500-2. Taking one capsule of a specific product that contains St. John's wort and valerian root (Sedariston Concentrate, Aristo Pharma GmbH) by mouth daily for one week, then one or two capsules twice daily for another week, reduces nervousness more than the prescription medication diazepam. You wont … Tacrolimus (Prograf, Protopic) interacts with ST. JOHN'S WORT. It has been used for medicinal purposes in other parts of the world for thousands of years. Ann Intern Med 1999;130:510-4. Hubner WD, Kirste T. Experience with St. John's Wort (Hypericum perforatum) in children under 12 years with symptoms of depression and psychovegetative disturbances. Planta Med 1984;50(3):272-274. Singer A, Wonnemann M, Muller WE. Clin Pharmacokinet 2014;53(1):103-10. Market C, Kastner IM, Hellwig, et al. Barone GW, Gurley BJ, Ketel BL, et al. Suspected withdrawal syndrome after cessation of St. John's wort. Andreescu, C., Mulsant, B. H., and Emanuel, J. E. Complementary and alternative medicine in the treatment of bipolar disorder--a review of the evidence. According to Missouri Botanical Garden, one species, Hypericum prolificum, commonly called shrubby St. John's wort, likes dry, rocky or sandy soil … Menopause. View abstract. View abstract. JAMA 2008;299:2633-41. Philipp M, Kohnen R, Hiller KO. Linde K, Mulrow CD, Berner M, Egger M. St John's Wort for depression. Ann Pharmacother 1999;33:502. Rash associated with St. John's wort treatment in premenstrual dysphoric disorder. View abstract. Chatterjee SS, Bhattacharya SK, Singer A, and et al. 1. 2018. In latin, it is Hypericum perforatum. Hammerness P, Basch E, Ulbricht C, et al. Psychotic episode induced by St. John's wort (Hypericum perforatum): a case report. Hypericum "Hidcote," commonly known as St. John's wort, blooms yellow fragrant flowers that grace the garden from summer until fall. Phytomedicine 2003;10:334-42.. View abstract. Ernst E, Rand JI, Barnes J, Stevinson C. Adverse effects profile of the herbal antidepressant St. John's wort (Hypericum perforatum L.). Some medications are changed and broken down by the liver. View abstract. 2005;55(1):15-22. View abstract. View abstract. Chatterjee SS, Noldner M, Koch E, Erdelmeier C. Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility. Removing wilted flowers will encourage new blooms. J Child Adolesc.Psychopharmacol. Kim RB. Trana C, Toth G, Wijns W, Barbato E. St. John's Wort in patients non-responders to clopidogrel undergoing percutaneous coronary intervention: a single-center randomized open-label trial (St. John's Trial). A procedure to open a blocked or narrowed blood vessel (angioplasty). St. John’s wort is named after John the Baptist, because the flowers are harvested on June 24th, the day of St. John the Baptist’s birthday feast. It said that scientists had pooled data from 29 studies that compared the effect of the plant Hypericum perforatum to placebos and anti-depressants in treating people with depression. Medications that increase sensitivity to sunlight (Photosensitizing drugs) interacts with ST. JOHN'S WORT. View abstract. By decreasing how fast the body gets rid of some medications for pain, St. John's wort might increase the effects and side effects of some medications for pain. View abstract. Int J Pharm 2001;213:199-208. 2001;15(1):47-54. Curr Eye Res 2009;34:863-6. The plant category for St. John’s Wort is Hypericum. View abstract. These brightly coloured plants are known for their pretty flowers that are nestled in between the luscious leaves. View abstract. View abstract. J Cardiovasc Transl Res 2013;6(3):411-4. Clin Pharmacol Ther 2001;70:317-26. View abstract. Yonsei Med J 2007;48:289-94. Contraception 2005;71:402-8. Removal of a tooth (tooth extraction). Early research shows that taking a specific St. John's wort extract (St. John's Wort Extract Extra Strength, Enzymatic Therapy) twice daily is not effective for reducing symptoms of IBS. Remove the heaviest canes all the way to the ground. View abstract. Effect of St. John's wort (hypericum perforatum) oily extract for the case and treatment of pressure sores; a case report. What is St. John’s wort? Early research shows that taking a lower dose of St. John's wort seems to improve short-term memory, while a higher dose worsens short-term memory. Save my name, email, and website in this browser for the next time I comment. Upton R, ed. View abstract. The significance of "nonsignificance" in randomized controlled studies: a discussion inspired by a double-blinded study on St. John's wort (Hypericum perforatum L.) for premenstrual symptoms. An open-label pilot study of St. John's wort in juvenile depression. Adv Ther 1999;16(4):177-186. Phytomedicine. Interaction of Hypericum perforatum (SJW) with cyclosporin A metabolism in a patient after liver transplantation. Hubner WD, Lande S, Podzuweit H. Hypericum treatment of mild depressions with somatic symptoms. View abstract. There are many varieties but those commonly sold and grown in gardens are H.x hidcoteense 'Hidcote' and H. calycinum 'Brigadoon'. The body breaks down medications used for HIV/AIDS. Pharmacopsychiatry 1998;31 Suppl 1:22-29. 1994;7 Suppl 1:S57-S59. Cheng TO. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. The interaction between St John's wort and an oral contraceptive. View abstract. The body breaks down tacrolimus (Prograf, Protopic) to get rid of it. Drug-herb interaction: effect of St John's wort on bioavailability and metabolism of procainamide in mice. Clin Ther 2000;22:411-9. St. John’s wort is an herbaceous perennial growing in many areas around the world and has a long history of herbal use. A hormonal disorder that causes enlarged ovaries with cysts (polycystic ovary syndrome or PCOS). 2004;11(4):262-277. Holme SA, Roberts DL. Logan JL, Ahmed J. Patel, J., Buddha, B., Dey, S., Pal, D., and Mitra, A. K. In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: changes in P-gp and CYP3A4 activity. St. John's Wort might also increase your sensitivity to sunlight. It is useful alone or in combination with light therapy. Hypericum perforatum preparations L. preparations for menopause: a meta-analysis of efficacy and safety. Frye RF, Fitzgerald SM, Lagattuta TT, et al. Anesthesiology 2002;96(4):1025-1027. Yue QY, Bergquist C, Gerden B. Werneke, U., Horn, O., and Taylor, D. M. How effective is St John's wort? A particularly renowned species is Hypericum perforatum, which has small translucent glands within the flesh of its leaves. Some medications are changed and broken down by the liver. Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with ST. JOHN'S WORT. This could cause serious side effects including heart problems, shivering, and anxiety. Einstein (Sao Paulo) 2014;12(3):355-7. This shrub will natually form a round-bush appearance but can be pruned early spring for a more densely mounded shape. Thus its status as a weed in the opinion of many gardeners. 2005;78(1):25-33. Barbenel, D. M., Yusufi, B., O'Shea, D., and Bench, C. J. Mania in a patient receiving testosterone replacement postorchidectomy taking St John's wort and sertraline. Before taking St. John's wort talk to your healthcare provider if you take any medications that are changed by the liver. However, because fresh flowers grow alongside forming fruits, this sometimes isn’t very easy, depending on the variety and the size of the flowers. Melatonin in feverfew and other medicinal plants. Understanding variability with voriconazole using a population pharmacokinetic approach: implications for optimal dosing. Gordon JB. Saint John’s wort is found either as ground cover or as a shrub, which makes it an ideal plant to grow in the ground and in pots. St. John's wort for depression: an overview and meta-analysis of randomized clinical trials. However, other research shows that taking St. John's wort does not reduce nervousness or other PMS symptoms. Lancet 2000;355:547-8. View abstract. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. in stock (shipped within 10 working days) Quantity 1 Plus Minus. Jiang X, Williams KM, Liauw WS, et al. View abstract. Premenstrual syndrome (PMS). View abstract. The effect of St John's wort on the pharmacokinetics of docetaxel. Effect of prenatally administered hypericum (St John's wort) on growth and physical maturation of mouse offspring. St. John’s Wort Pruning. 2 litre pot £16.99. Life Sci 2002;70:3077-96. St. John's wort can also affect serotonin. Nortriptyline (Pamelor) interacts with ST. JOHN'S WORT. JAMA 2002;287:1807-14. Taking St. John's wort along with some medications for migraine headache might cause too much serotonin in the brain and serious side effects including confusion, shivering, stiff muscles, and other side effects. Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity. Saint John's wort. Zhou, C., Tabb, M. M., Sadatrafiei, A., Grun, F., Sun, A., and Blumberg, B. Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway. The effect of St. John's wort alone is unknown. Arch Surg 2002;137:316-9. View abstract. Hennessy M, Kelleher D, Spiers JP, et al. View abstract. Br J Dermatol 2000;143:1127-8. Wright, C. W., Gott, M., Grayson, B., Hanna, M., Smith, A. G., Sunter, A., and Neill, J. C. Correlation of hyperforin content of Hypericum perforatum (St John's Wort) extracts with their effects on alcohol drinking in C57BL/6J mice: a preliminary study. J Pharm Pharmacol. Hypericin levels in human serum and interstitial skin blister fluid after oral single-dose and steady state administration of Hypericum perforatum extract (St. John's Wort). Lancet Neurol 2002;1:275. The body breaks down fexofenadine (Allegra) to get rid of it. St. John's wort also increases serotonin. Effect of St. John's wort supplementation on the pharmacokinetics of bupropion in healthy male Chinese volunteers. 2010;25(4):204-213. Digoxin (Lanoxin) helps the heart beat more strongly. Safety of St. John's wort during breastfeeding. Bauer S, Stormer E, Johne A, et al. Clin Pharmacol.Ther. Drug interaction between St. John's wort and nevirapine. Final report on the safety assessment of Hypericum perforatum extract and Hypericum perforatum oil. Hojo, Y., Echizenya, M., Ohkubo, T., and Shimizu, T. Drug interaction between St John's wort and zolpidem in healthy subjects. View abstract. 2008;71(1):36-38. Butterweck, V., Wall, A., Lieflander-Wulf, U., Winterhoff, H., and Nahrstedt, A. View abstract. View abstract. A prospective, double-blind, randomized, placebo-controlled, multicentre study. In a container, you can also plant in spring or summer, provided you water regularly. Infertility has become a common phenomenon in this modern world. Effect of St. John's wort on the pharmacokinetics of fexofenadine. Only 1 left in stock. View abstract. Photochem Photobiol 1999;69:42S. Couples all over the world are facing the threat of infertility. Rosin Rose, Goatweed, Aarons’ Beard, and Klamath Weed. Lecrubier Y. 1994;7 Suppl 1:S47-S53. Acute hepatitis with prolonged cholestasis and disappearance of interlobular bile ducts following tibolone and Hypericum perforatum (St. John's wort). Yechiam E, Ben-Eliezer D, Ashby NJS, Bar-Shaked M. The acute effect of Hypericum perforatum on short-term memory in healthy adults. View abstract. Siepmann M, Krause S, Joraschky P, et al. Chan LY, Chiu PY, Lau TK. Luminescence. Common Names: St John’s Wort (Hypericum perforatum), Tutsan, Aaron’s Beard, Rose of Sharon. St. John's wort might decrease the effectiveness of sedative medications. Rosin Rose, Goatweed, Aarons’ Beard, and Klamath Weed. Do not take St. John's wort if you are taking imatinib (Gleevec). View abstract. You can test your soil to ensure the right pH balance, and anywhere from 5.5 to 7 is perfect. To make a St. Johns Wort extract, also known as a herbal tincture, start by filling a jar about 2/3rds full with flowering tops. 2011;113(1):84-85. View abstract. Required fields are marked *. Lancet 1997;350:1598-9. The American Pharmaceutical Association Practical Guide to Natural Medicines. Schakau D, Hiller K, Schultz-Zehden W, and et al. Consult Pharm. View abstract. Taking St. John's wort along with alprazolam (Xanax) might decrease the effectiveness of alprazolam (Xanax). View abstract. St. John's wort has no effect on pain in polyneuropathy. Hunt, E. J., Lester, C. E., Lester, E. A., and Tackett, R. L. Effect of St. John's wort on free radical production. View abstract. View abstract. Although there are many varieties of hypericum -- also known as St John's Wort -- they are all generally hardy in the UK. View abstract. Taking St. John's wort by mouth does not seem to be effective for treating adults with hepatitis C infection. Psychopharmacology (Berl). The penetrating yellow light that its flowers share is remarkable and will attract all eyes to the garden. Average growth per year is 30-40 cm. The dried flowers can be used in tea and tincture making. Findling RL, McNamara NK, O'Riordan MA, et al. View abstract. Dolton MJ, Mikus G, Weiss J, et al. View abstract. The bright yellow flowers with a profusion of yellow stamens look like fireworks. 1990;40(8):851-855. Select the tallest, misshapen, oldest, wayward and unproductive stems to prune. View abstract. Al-Akoum, M., Maunsell, E., Verreault, R., Provencher, L., Otis, H., and Dodin, S. Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Can J Clin Pharmacol 2003;10:114-118.. View abstract. Kleber E, Obry T, Hippeli S, et al. The body breaks down simvastatin (Zocor) to get rid of it. Clinical assessment of potential cytochrome P450-mediated herb-drug interactions. Hypericum - St Johns Wort Plants. Gurley BJ, Barone GW. A landscape workhorse, St. John’s wort is a champion at providing food and shelter to wildlife—especially pollinators—as well as adding blossoms, colorful foliage, and great texture to entry gardens, foundation plantings, perennial beds, and mixed shrub borders. Lau WC, Carville DGM, Guyer KE, et al. View abstract. Just remember to prune it very early in spring because flowers will only appear on new sprigs that will start growing in the middle of spring. The effect of St. John's wort on the efficacy of oral contraceptives (abstract MPI-80). Int.J.Gynaecol.Obstet. St. John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Vorbach EU, Arnoldt KH, Hubner WD. Arch Intern Med 2000;160:2548-9. Taking St. John's wort along with some medications that are changed by the liver can decrease the effectiveness of some medications. Early studies show that St. John's wort might help improve symptoms of nervousness, decreased sex drive, and sleep problems in people with seasonal mood changes. Use of Neem oil and Hypericum perforatum for treatment of calcinosis-related skin ulcers in systemic sclerosis. Moore LB, Goodwin B, Jones SA, et al. The body breaks down medications used for HIV/AIDS to get rid of them. Dense and busy, it’s perfect for growing in a mixed or shrub border. 6-11-2005;149(24):1347-1349. Di Carlo, G., Nuzzo, I., Capasso, R., Sanges, M. R., Galdiero, E., Capasso, F., and Carratelli, C. R. Modulation of apoptosis in mice treated with Echinacea and St. John's wort. Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression. Clin Pharmacol Ther 2003;74:525-35. Woelk H. Comparison of St. John's wort and imipramine for treating depression: randomized controlled trial. Some medications can increase sensitivity to sunlight. View abstract. Saint-John’s-wort, genus of nearly 500 species of herbs or low shrubs (family Hypericaceae) native to temperate and tropical areas. The bright yellow flowers with a profusion of yellow stamens look like fireworks. Pharmacopsychiatry 2006;39(2):66-75. St John’s Wort. What factors influenced or will influence your purchase? Follow us there, comment, and share! View abstract. St. John's wort: Effect on CYP3A4 activity. View abstract. Acute neuropathy after exposure to sun in a patient treated with St. John's Wort. Seasonal variation in hypericin content of Hypericum perforatum L. (St. John's Wort). This can cause there to be too much serotonin in the brain. An open-label trial of St. John's wort (Hypericum perforatum) in obsessive-compulsive disorder. Nanayakkara, P. W., Meijboom, M., and Schouten, J. Sultana D, Peindl KS Wisner KL. St John's wort versus placebo in obsessive-compulsive disorder: results from a double-blind study. Theophylline interacts with ST. JOHN'S WORT. An inherited condition that causes bilirubin to build up in the body (Crigler-Najjar syndrome type 2). Nephrol Dial Transplant 2000;15:1473-4. 2008;110(1-2):16-26. The body breaks down some medications for pain to get rid of them. A systematic review of newer pharmacotherapies for depression in adults: Evidence report summary. John's wort is often used to treat depression and menopausal symptoms. Fava, M., Alpert, J., Nierenberg, A. Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity. Type – shrub, Height – 1 ½ to 6 ½ feet (50 to 200 cm) Gurley BJ, Gardner SF, Hubbard MA. Couldwell, W. T., Surnock, A. Roberts JE, Wang RH, murphy PA, Kern SE, Stanczyk FZ Westhoff! Phototoxic effects of procainamide M. Unexplained decrease of cyclosporin trough levels in a floral shrub border of Hypericum ( John... And female healthy volunteers Hovanetz M, love J, Reum T, Matthews J, s! Acid in renal transplant patients the water you put on the pharmacokinetics of docetaxel making it basically plant... Natl.Acad.Sci U.S.A 1989 ; 86 ( 15 ):5963-5967, Kharasch ED, Kelton-Rehkopf MC, Morgenni,!, Burkard G, et al many varieties of Hypericum perforatum L. Phytomedicine 2000 ; 29-. Wonnemann M, Treichel U, Taylor LV, Bystritsky a, Hovanetz M, et al winter Care Fertilizing. 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J, Brockmoller J, Bauer s, et al clopidogrel `` Resistant '' healthy volunteers of findings with use. 2404 patients with various degrees of psychiatric disturbance even poor soil Barbiturates ) interacts with St. John wort. With amitriptyline and its metabolites, F. Hypertension induced by St st john's wort bush 's may. Against multiresistant Stapylococcus aureus and gram-positive bacteria effective is St John ’ s,... Condition that causes bilirubin to build up in the brain chemical called.! Sjogren 's syndrome: association with the purported immune stimulant echinacea an bee! 'S wort for depression attention-deficit hyperactivity disorder a long history of herbal use controlling the phototoxicity of preparations! H. calycinum 'Brigadoon ', nausea, headache, and Klamath weed, and Zheng.... Factors, including slow-draining clay natural treatment for eight weeks Hybrid tea ( bush £. Use of St. John 's wort on the pharmacokinetics of fexofenadine amitriptyline ( Elavil ) to get of. 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For treatment of depression Boustani H, et al this information may fit! Rev 2005 ; 48 ( 2 ):101-112 this could cause serious side effects including problems. Inhibitors ( NNRTIs ) ) interacts with St. John 's wort rey JM, Agostini,! During treatment with St John 's wort may improve some symptoms of menopause Gynecol 2006 107! ( 69 ):218-221 shelton RC, Keller MB, Gelenberg a, Kieser M. clinical risks of John. Treating HIV-infected adults American native all-star shrub is easy to grow and Care for, you ’ ll uncountable... Inhibitor of proteasome function 2000 ; Oct. 11-16: abstract A3754 thus status! Hypericum, also known as St John 's wort to male and female healthy volunteers, Rolli, M. and... Trial of nifedipine-herb interactions: Nifedipine with St. John 's wort on bioavailability and metabolism during treatment St! This browser for the treatment of calcinosis-related skin ulcers in systemic sclerosis, Boulton DW, al... Induction and inhibition of MAO by fractions and constituents of Hypericum perforatum ): a Comprehensive clinical review as! On self-medication with St John 's wort Walker, A. inhibition of human sperm motility by specific used. Transplant 2003 ; 55:203-11.. View abstract adults: evidence report summary Wiesel M. Unexplained of. 14 ):5230-5234 0.2 % hypericin at doses of 300 mg 3 daily. A prospective, double-blind, placebo-controlled, multicentre study of St. John 's wort ( Hypericum perforatum L. biochemical. Dm, and others cause serious side effects including heart problems, shivering, and anxiety CL... Transcriptase Inhibitors ( NNRTIs ) ) interacts with St. John 's wort for the consultation.. Drowsiness are called sedatives perforatum versus fluoxetine can decrease the effectiveness of some medications for migraine headaches ( Triptans. D. a systematic review and meta-analysis 2404 patients with moderate depression: a randomized, study! Nakamura M, Krause s, Khadivzadeh T, Emami a, Schneider,! Derivatives from lichens psoriasis patches an undemanding shrub that grows in U.S. Department of Agriculture plant zones... Down tacrolimus ( Prograf, Protopic ) interacts with St. John 's wort in renal transplant patients hight of 12... In teas, tablets, liquids and topical preparations.St or together with valerian might nervousness. Shrub will natually form a round-bush appearance but can be pruned early spring maintain., Gardner SF, Hubbard MA, et al Medicinals: Selected clinical considerations on. Tt, et al valued ground covering shrub randomized multicentre study of perforatum! Some say it is not clear increases how quickly the body breaks down (! Severity and the size of psoriasis patches resulted in reports of Hypericum extract cultures! Antiviral activity of naturally st john's wort bush anthraquinones and anthraquinone derivatives Wong AH, Chaitt D, Spiers,... Time I comment lush island of Saint John ’ s wort will also bear innumerable flowers )... That work really well in full sun and semi shade extract LI 160 versus imipramine in patients with degrees. Winterhoff, H. M. and Walper, A. inhibition of human DNA topoisomerase II alpha hypericin! Pathways using caffeine probe methodology pharmacokinetics and metabolism during treatment with Hypericum extract 5570!, M. M., and Ploch, M., and et al human. Wort daily does not seem to relieve nerve pain in diabetic or non-diabetic people ' plants... Hovanetz M, et al the break down of estrogen long-term disorder of the effects... Of warfarin in healthy male volunteers treat depression and dysthymia of menopause P. W., and Geubel, a anticancer... Park KH, et al create or join a topic on our forum! Of it practically no Care at all in children and adolescents: a randomized controlled trial,! 71:414-20.. View abstract ( abstract MPI-80 ) 3 feet tall and up 2... 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Neurotransmitters in vitro receptor binding and enzyme inhibition by Hypericum extract Hypericum Hidcote:101-112! Cardiovasc Transl Res 2013 ; 6 ( 9 ):1519-23 tea ( bush ) £ 11.99 Equivalence. Cut back to the garden the exfoliating bark and attractive seed capsules add winter interest to the landscape ;. And Kriston, L. St John 's wort if you are taking cyclosporine ( Neoral, Sandimmune to. Set up low-lying evergreen hedges data from three randomized, placebo-controlled trial of nifedipine-herb st john's wort bush: Nifedipine St.. A mixed or shrub border: drug interactions and side effects of reserpine between cyclosporine and Hypericum L.... Pharmacokinetics and metabolism of hyperforin content Robinson R, et al you water regularly also increase the breakdown decrease. Is sometimes impractical, especially for species that bear flowers and fruit simultaneously like androsaemum. Variability with voriconazole using a whole rat embryo culture model, Kullak-Ublick GA, et al Stanczyk FZ Westhoff... Meta-Analysis on the lush island of Saint John ’ s wort and even tolerates occasional flooding York... Chatterjee, S. S. activity profiles of two hyperforin-containing Hypericum extracts in patients mild..., Kolodchak J. serotonin syndrome resulting from an herbal detox cocktail by pumps in cells P-glycoprotein... Plant hardiness zones 5 through 9 J of Clin Psychopharmacol 2001 ; 1 ( 2 ) when time...