ABSTRACT: An association between age and prostate-specific antigen (PSA) has been documented: As men age, their serum PSA value increases. Two-thirds of Australians support pill testing at festivals: Survey. Post-chemotherapy, there is no compelling evidence that one agent is superior to another, and patient factors are again the main drivers of choice. Eur Urol 2015;68(3):438â50. doi: 10.1016/j.eururo.2017.02.026. This changed in 2004 when the taxane chemotherapeutic agent docetaxel was reported to prolong survival for patients with metastatic CRPC.23 This has been followed by the approval of a slew of new systemic agents over the past 15 years, all of which are administered in combination with ADT and have been shown to improve survival,24 further increasing the therapeutic options available to patients (Table 1). Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): Survival results from an adaptive, multiarm, multistage, platform randomised controlled trial. MRI-targeted or standard biopsy for prostate-cancer diagnosis. The PSA testing guidelines published by the Prostate Cancer Foundation of Australia/Cancer Council Australia (and endorsed by the National Health and Medical Research Council) contain detailed information about who should be offered PSA testing and the supporting evidence. Prostate MRI, with or without MRI-targeted biopsy, and systematic biopsy for detecting prostate cancer. There has also been an increasing recognition of the association between germline DNA repair defects and progressive disease, and interest in the potential to identify patients for therapies that target these defects. Supporters hope public pressure will lead to policy changes, but opponents maintain âno pill is safeâ. N Engl J Med 2015;373:1697â708. Magnetic resonance imaging-targeted biopsy may enhance the diagnostic accuracy of significant prostate cancer detection compared to standard transrectal ultrasound-guided biopsy: A systematic review and meta-analysis. Sweeney CJ, Chen Y-H, Carducci M, et al. doi: 10.1056/NEJMoa1911206. Australian
taken to reproduce articles accurately, but the publisher accepts no responsibility for errors, omissions or MP3 Most web browsers will play the MP3 audio within the browser, Your comment is being submitted, please wait. There have been significant changes in how prostate cancer is diagnosed and managed in the past five years, with the introduction of new clinical pathways that were unprecedented just a decade previously. is published by The Royal Australian College of General Practitioners, Prostate specific antigen is tissue-specific but not cancer-specific. Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET): A randomised, phase 2, open-label trial. Bruinsma SM, Bangma CH, Carroll PR, et al. Prostate cancer accounted for the second highest number of male cancer deaths in Australia. more confidence, whether the elevated PSA is more likely to be associated with prostate cancer than be due to non-cancerous changes, potentially avoiding unnecessary biopsy. Drost FH, Osses DF, Nieboer D, et al. This article forms part of our ‘Tests and results’ series for 2011 which aims to provide information about common tests that general practitioners order regularly. It makes recommendations on how best to support men in making an informed decision for or against PSA testing and on which testing protocol to recommend to men who decide in fâ¦ Prostate imaging reporting and data system version 2.1: 2019 update of prostate imaging reporting and data system version 2. To open click on the link, your computer or device will try and open the file using compatible software. Chi KN, Agarwal N, Bjartell A, et al. N Engl J Med 2016;375(5):443â53. doi: 10.1001/jama.2018.3712. Prostate specific antigen (PSA) is a glycoprotein produced solely by the prostate. RACGP is the latest medical college to endorse the guidelines, which provide health professionals with evidence-based recommendations for using the prostate specific antigen (PSA) blood test to assess prostate cancer risk and manage test-detected patients. Tailored information for general practices to manage Page 5/9. N Engl J Med 2004;351(15):1502â12. doi: 10.1200/JCO.19.00799. All rights reserved. Journal of
Another area of ongoing interest is the concept of oligometastatic disease, which is well established in other tumours and posits that some patients with a limited number of metastases (<3 or <5, depending on the author) may represent a ‘curable’ metastatic state. Can J Urol 2016;23(2):8247â53. Prostate specific antigen is tissue-specific but not cancer-specific. Detection of clinically significant prostate cancer using magnetic resonance imaging-ultrasound fusion targeted biopsy: A systematic review. doi: 10.1016/j.eururo.2016.08.041. Published ( 2016 ) Carducci M, et al has traditionally been used the. Brackets along with the filesize of the documents on this site are in Portable Document format PDF... Foundation of Australia all Sections clinical Professional RACGP GP Opinion Videos & Podcasts key to who. Tumour type in Australian men practice guidelines PSA testing refers to PSA testing,! 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